Allergy & Immunology

Allergic sensitisation is dynamic across ages in a 5,046-person Austrian cohort

In 5,046 participants with three skin-prick test visits over a mean 4.25 years, 54.4% remained non‑sensitised and 30.6% remained sensitised. Resolution occurred in 5.6%, new onset in 4.8%, and fluctuation in 4.6% of participants. New sensitisation clustered to outdoor allergens and occurred into adulthood, while fluctuation related to seasonal pollens, environmental exposures, and adult adiposity. Stable sensitisation associated with parental allergy and blood eosinophils; cumulative smoking modestly reduced stability. 1

Cough-predominant phenotypes common and linked to poor control in 20,683 Chinese hospital asthma patients

Among 20,683 outpatients, 22.8% had uncontrolled and 39.5% had partially controlled asthma; cough was present in 80.0%. Cough-dominant and cough-variant phenotypes were common (14.6% and 11.4%, respectively). Cough severity independently predicted poor control, with stronger associations in patients using inhaled corticosteroids. Only 21.4% had used ICS in the prior year despite high exacerbation and hospitalization rates. 2

Systematic review finds insufficient evidence to support allergen immunotherapy for eosinophilic esophagitis

EAACI review identified four studies evaluating AIT in EoE, mainly pediatric milk EPIT from the SMILEE program. The randomized EPIT trial did not show a significant difference in tissue eosinophilia versus placebo, though 47% of treated patients tolerated milk without recurrence in follow-up. Open‑label and mechanistic data suggested immunologic changes but clinical benefit was inconsistent and not definitive. SCIT evidence was limited and retrospective, producing inconclusive results. 3