Dermatology

Online connected-health care is equivalent to in-person care for atopic dermatitis at 12 months

In a pragmatic randomized equivalence trial of 300 patients with AD, online team-based connected health (TCH) produced equivalent 12-month improvements versus in-person care. Primary and secondary outcomes (EASI, POEM, vIGA) all fell within prespecified equivalence margins. Participants were adults and children with internet and photograph access, supporting applicability to patients able to engage remotely. Consider TCH as an effective management option for chronic AD when patients can reliably provide photos and remote follow-up. 1

Dermatologist-performed TBSEs in an academic program detect early skin cancer with modest biopsy burden

In 3,127 screening encounters from 1,572 participants, TBSEs detected premalignant lesions in 11.0% and malignant lesions in 2.6% of exams. Overall number needed to biopsy was 4.83, improving across rounds from 6.10 to 2.79. Detection rates were highest in older adults and those with prior nonmelanoma skin cancer. Be aware of voluntary participation and possible selection bias when extrapolating yields to general populations. 2

DOOR endpoint applied to ABSSSI trials shows similar overall outcomes for omadacycline and linezolid

A DOOR endpoint incorporating clinical response, complications, serious adverse events, and mortality was constructed for ABSSSI trials. Retrospective DOOR application to OASIS-1 and OASIS-2 showed near-even probabilities of a more desirable outcome with omadacycline (50.6% and 52.1%). Using SF-36 as a tiebreaker in OASIS-2 did not materially change results. DOOR offers patient-centered trial interpretation but requires prospective use before changing prescribing practice. 3