Infectious Diseases

High early mortality in Vibrio vulnificus despite empirical antibiotics; surgery and lactate predict outcome

In a 6.5‑year multicenter Thai cohort of 49 adults with culture‑confirmed Vibrio vulnificus, disease was fulminant with 83.7% bacteremia. Most required organ support (61.2% mechanical ventilation; 75.5% vasopressors), and necrotizing skin‑soft‑tissue infection was common (~66%). Seven‑day mortality reached 49%, with 42.9% dying within 48 hours despite 91.8% receiving empirical antibiotics. Elevated serum lactate and omission of surgical treatment were independently associated with early death, supporting urgent surgery and aggressive resuscitation. 1

Infection is common in idiopathic inflammatory myopathies; anti‑MDA5 and RPILD strongly increase risk

Meta‑analysis of 14,548 patients with idiopathic inflammatory myopathies found pooled infection prevalence 24% (95% CI 18–31%). Anti‑MDA5 positivity conferred higher infection odds (OR 3.41) and rapidly progressive ILD raised risk (OR 1.91). Lower lymphocyte counts and low albumin associated with infection, and several immunosuppressive regimens increased risk. TMP‑SMX prophylaxis was associated with lower infection odds (OR 0.21), suggesting prophylaxis consideration in high‑risk subgroups. 2

The Danish Infection Cohort: linked registry resource quantifying infections and risk factors

The cohort links national survey and registry data for 609,224 adults across four survey years to capture infections in the following 365 days. Overall, 32.3% had ≥1 infection and the dataset recorded 315,689 infections (community‑treated and hospital‑diagnosed). Respiratory infections were most common and antibiotics accounted for 80.6% of anti‑infective prescriptions. The resource includes behavioral and clinical variables enabling population‑level infectious disease and risk‑factor studies. 3