Nephrology

Kidney genetics clinics show high diagnostic yield across models

A scoping review of 60 studies found overall 92% diagnostic yield reported across kidney genetics programs. Nephrologist-led clinics performed comparably to multidisciplinary models when adequately supported. Model distribution reflected regional funding, laboratory access, and resources, influencing testing approaches. Outcome reporting was sparse for timeliness (16%), patient-reported outcomes (12%), and implementation outcomes (4%), limiting assessment of real-world impact. 1

SONG-LP validated for life participation measurement in dialysis

The SONG-LP instrument demonstrated strong internal consistency (Cronbach's α 0.89) in 250 adults receiving dialysis. Test-retest reliability over one week was acceptable (ICC 0.76) and SONG-LP correlated with PROMIS APS and EQ-5D. These psychometric results support using SONG-LP as a core outcome measure of life participation in dialysis trials. Further evaluation is warranted when applying SONG-LP across different languages or clinical settings. 2

KDIGO emphasizes education and local implementation to close guideline-practice gaps

KDIGO outlines a strategy of “global guidance, local implementation” using education, summits, and digital tools. The manuscript argues guideline development alone is insufficient to change practice without dissemination and clinician and patient education. Successful adoption requires adaptation to local systems and active implementation efforts to optimize patient outcomes. 3