Nuclear Medicine

Registered trials of ayahuasca/DMT are early-phase and safety-focused

This scoping review identified 26 registered interventional trials of DMT, ayahuasca, or DMT+harmine on ClinicalTrials.gov. Most trials were phase I, concentrated on acute safety, physiological monitoring, and subjective state characterization. Only a minority of completed programs prioritized disorder-specific symptom endpoints, with a small subset showing preliminary depression signals. Clinical implication: the evidence base supports regimen and tolerability knowledge but is not yet sufficient for broad therapeutic adoption. 1

PSMA PET improves staging but real-world utility needs standardization

PSMA PET shows superior diagnostic performance versus conventional imaging for prostate cancer staging. Interpretation variability arises from scanner design, detector technology, accreditation, and reader expertise. Authors recommend standardized reporting, accreditation, education, and AI tools to improve consistency. They caution that clinical benefit on patient outcomes requires prospective, outcome-driven validation. 2

Emulated clinical trials can estimate comparative clinical utility of dynamic treatment rules

The authors formalize emulated trial methods to compare a proposed dynamic treatment regime to the standard physician-assigned care. They present several estimators and practical steps for implementation using observational data. A rheumatoid arthritis example illustrates comparing an 'optimal' rule to standard care and guideline-based care. Caveat: results depend on observational data quality and assumptions required for causal emulation. 3