Obstetrics & Gynecology

Pregnancy or recent childbirth not independently linked to worse distant recurrence in young early-stage breast cancer

In a prospective cohort of 859 women ≤40 years with stage I–III breast cancer, pregnancy or postpartum status at diagnosis was not independently associated with distant recurrence–free survival after multivariable adjustment. Pregnant patients presented with more aggressive tumor features, including higher rates of TNBC, nodal involvement, T3/T4, and grade 3 tumors. After median 11.1 years follow-up, adjusted analyses showed comparable DRFS across ER+/HER2-, HER2+, and TNBC subtypes. Sensitivity analyses using alternative postpartum timing categorizations produced consistent results. 1

No US data on endometriosis and preeclampsia/eclampsia specifically in Black women

This scoping review screened 370 records and found no US-based studies meeting criteria for Black reproductive-aged women with laparoscopically confirmed endometriosis reporting preeclampsia/eclampsia outcomes. Most excluded studies lacked race-stratified outcomes or were conducted outside the US, creating a critical evidence gap for clinical guidance. The review highlights the need for race-conscious, US-based research before changing screening or management for endometriosis in Black women. 2

Obstetric complications more common in those at clinical high risk for psychosis

Meta-analysis of nine studies (555 CHR participants) found higher prevalence of obstetric complications in CHR individuals versus controls (RR 1.45, 95% CI 1.16–1.81). Three longitudinal studies suggested a trend toward increased transition to psychosis with prior OCs (RR 2.05, 95% CI 0.98–4.26), but this did not reach conventional significance. Authors recommend recording and analyzing obstetric complication history in CHR assessments, while recognizing the need for further longitudinal data. 3