Ophthalmology

High glaucoma conversion in pseudoexfoliation, even without ocular hypertension

In this tertiary-center cohort of 485 PXF eyes, 4-year perimetric glaucoma incidence was 26.5% without ocular hypertension and 37.5% with it. Older age, ocular hypertension, higher baseline cup–disc ratio, and phakia independently increased glaucoma risk on Cox regression. Incident ocular hypertension developed in 14.6% of initially normotensive PXF eyes during follow-up. Notably, 87.3% of eyes that developed glaucoma never had documented ocular hypertension at any office visit. 1

IRIS Registry benchmarks endophthalmitis risk across common eye surgeries

Across 17,457,881 IRIS Registry procedures, 30-day endophthalmitis incidence varied markedly by surgery type and age. Among adults, risk was highest after open globe repair (0.94%) and around 0.1% after vitrectomy for retinal detachment or trabeculectomy. Adult cataract surgery had 0.038% endophthalmitis, similar to standalone MIGS and higher than goniotomy or strabismus surgery. Pediatric patients had higher endophthalmitis rates than adults after cataract and scleral buckle, with similarly high risk after open globe repair. 2

Early response features predict 90-day vision in microbial keratitis

This US–India cohort related presenting characteristics in microbial keratitis to 90-day best-corrected visual acuity. Investigators also assessed early treatment response parameters as predictors of subsequent visual outcomes. The study identifies clinical features usable for early risk stratification and patient counseling about prognosis. Findings aim to inform intensity of follow-up and consideration of adjunctive therapies in high-risk cases. 3

Cultured endothelial cell injection after failed DSAEK shows large visual gains

Four eyes with endothelial graft failure after DSAEK received intracameral cultured human corneal endothelial cell therapy. Mean BCVA improved from 1.93 to 0.46 logMAR at three months, roughly from 20/1700 to 20/60. Central corneal thickness decreased from 900 to 641 µm, and endothelial cell density reached 2150 cells/mm² at three months. Mean IOP increased modestly from 10 to 13 mmHg, without pressure complications or graft detachment. 4