Psychiatry

Proposes CGI 2.0 standards to reintegrate calibrated clinician judgment in drug trials.

Clinical judgment can capture contextual change that multi-item scales may miss. Authors propose "CGI 2.0": rater qualification, construct-focused training, structured justification, and calibration monitoring. They recommend prespecified concordance/discordance analyses between clinician global ratings and primary symptom scales. This is a conceptual analysis intended to guide trial design rather than provide empirical outcome data. 1

Scoping review maps 681 ongoing/planned RCTs of digital psychotherapies for adult depression.

Among 681 registered RCTs (2018–2025), 51.8% were completed and 34.1% had published results. Most trials used self-reported outcomes, CBT modalities, and open-label designs; human support occurred in 44.2%. Many trials rely on waitlist or no-treatment controls and underrepresent active controls and timely result dissemination. Authors call for active controls, faster reporting, and trials in underserved populations to strengthen future evidence. 2

Large cohort shows remote psychiatry is generally non-inferior, with risks in schizophrenia-spectrum patients.

Five annual cohorts yielded 106,153 observations assessing remote consultation proportion and clinical outcomes. Higher remote use was not linked to worse outcomes for most diagnoses, supporting general safety of remote care. For schizophrenia-related disorders (F20–F29), greater remote use associated with higher odds of hospitalisation (OR 1.06, 95% CI 1.03–1.09). Findings come from observational EHR data and cannot prove causation, so interpret diagnostic risks cautiously. 3