Sleep Medicine

Rising SBP trajectories in untreated OSA predict higher cardiovascular events; CPAP associated with lower events.

In 624 untreated OSA patients followed for 10 years, three systolic blood pressure (SBP) trajectories emerged: stable, falling, and rising. The rising SBP trajectory carried higher cardiovascular risk (adjusted HR 2.84, 95% CI 2.13–3.78) versus stable trajectory. CPAP use was associated with reduced cardiovascular events (adjusted HR 0.62, 95% CI 0.45–0.84) and greater SBP reduction with longer nightly use. Findings apply to patients with OSA not receiving antihypertensive therapy and derive from observational and complementary trial analyses. 1

Insomnia symptoms prevalent (32%) with small macrostructural but consistent microstructural PSG differences.

In a population-based Swiss cohort (n=3,947; mean age 57.5), insomnia symptoms affected 32.0% of participants. Polysomnography in 1,718 participants showed shorter total sleep time, longer sleep onset latency and wake after sleep onset, and lower sleep efficiency (small effects). EEG microstructure differences were more consistent, including higher ORP and increased beta and gamma power, though effect sizes were small. Independent correlates included older age, female sex, lower education, cardiometabolic factors, mood symptoms, psychotropic use, and daytime sleepiness. 2

Insufficient sleep linked to higher odds of suicidal behaviors in Chinese adolescents.

Baseline survey of 12,779 Chinese adolescents (mean age 13.5) found past-year suicidal ideation, plans, and attempts at 18.2%, 8.8%, and 5.2%, respectively. After multivariable adjustment, insufficient sleep versus optimal sleep was associated with suicidal ideation (OR 1.32, 95% CI 1.18–1.48), plans (OR 1.22), and attempts (OR 1.32). Sensitivity and subgroup analyses supported robustness, and excessive sleep showed no significant associations. This cross-sectional study cannot prove causation but supports assessing sleep duration in adolescent mental-health evaluations. 3