30-Second Takeaway
- Educational audit-and-feedback programs reliably reduce inappropriate urinary antibiotic prescribing in aged care.
- BOOP performed after radiotherapy is associated with substantially higher GU morbidity than BOOP before radiotherapy.
Week ending May 30, 2026
Grand Rounds: Selected recent urology evidence briefs
Bladder outlet procedures after prostate radiotherapy carry higher GU toxicity
This TriNetX retrospective cohort compared BOOP after XRT (n=447) versus before XRT (n=1504) with propensity matching (final matched n=411 per group). BOOP after XRT had higher risks of stress incontinence (RR 4.29), urge and mixed incontinence, urinary retention, bladder neck contracture, and urethral strictures versus BOOP before XRT. Minimally invasive procedures had limited sample size and suggested no clear difference, whereas resective surgery after XRT showed greater harm than resective surgery before XRT. Clinical implication: evaluate and, when appropriate, treat bladder outlet obstruction before initiating radiotherapy to potentially reduce postprocedural GU morbidity.
P3-BC web decision aid is feasible and acceptable for cystectomy candidates
Investigators developed P3-BC and randomized 15 patients in a small feasibility trial with high program access and retention (100% accessed, 93% retention at 1 month). Acceptability was high (86% satisfied; 86% ease of use) despite a 21% consent rate among eligible patients. No statistically significant clinical outcome differences were seen, though trends favored reduced decisional conflict and symptom burden in the intervention arm. This tool is ready for an adequately powered randomized trial before routine adoption in clinical practice.
Micro- and nanoplastics enriched in urological tumour tissue in human studies
This systematic review of 14 human cross-sectional studies detected micro- and nanoplastics (MNPs) across kidney, prostate, testis, penis, ureter, and occasionally bladder. All studies that compared malignant versus adjacent non-malignant tissue reported higher MNP burden or greater polymer diversity in tumours. Heterogeneity in analytical methods, digestion protocols, and reporting limits comparability and precludes causal inference. Clinical implication: current data are hypothesis-generating regarding oncogenesis and warrant standardized methods and further translational research before clinical application.
References
Numbered in order of appearance. Click any reference to view details.
Additional Reads
Optional additional studies from this edition.